(2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

Base Information

• Chemical Name: (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid
• CAS No.: 1609006-19-0
• Molecular Formula: C₂₅H₃₉NO₆
• Molecular Weight: 449.588

Synonyms:(2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

Chemical Property of (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

There total 3 articles about (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2S,4R)-4-(4-tert-butylbenzyl)-di-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate (1609006-17-8) → (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid (1609006-19-0)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at -10 - -5 ℃; for 1h;

DOI:10.1016/j.tetasy.2014.03.016

Reference yield:

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate (91229-91-3) → (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid (1609006-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 1 h / -10 - -5 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; water; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2014.03.016

Reference yield:

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid (1609006-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 1 h / -10 - -5 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; water; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2014.03.016

upstream raw materials:

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

(2S,4R)-4-(4-tert-butylbenzyl)-di-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

Downstream raw materials:

(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

(2S,4R)-tert-butyl 4-(4-tert-butylbenzyl)-2-((tert-butoxycarbonyl)amino)-5-(ethylamino)-5-oxopentanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1609006-19-0 (2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send