(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Base Information

Chemical Name:(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid
CAS No.:1609006-23-6
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

Synonyms:(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

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Chemical Property of (2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

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Technology Process of (2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

There total 5 articles about (2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1609006-21-4
(2S,4R)-tert-butyl 4-(4-tert-butylbenzyl)-2-((tert-butoxycarbonyl)amino)-5-(ethylamino)-5-oxopentanoate

: 1609006-23-6
(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2014.03.016

Reference yield:

: 1609006-17-8
(2S,4R)-4-(4-tert-butylbenzyl)-di-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate

: 1609006-23-6
(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran / 1 h / -10 - -5 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C

With water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2014.03.016

Reference yield:

: 1609006-19-0
(2R,4S)-2-(4-tert-butylbenzyl)-5-tert-butoxy-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid

: 1609006-23-6
(2S,4R)-4-(4-tert-butylbenzyl)-2-amino-5-(ethylamino)-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2014.03.016