1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

Base Information

Chemical Name:1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn
CAS No.:346700-28-5
Molecular Formula:C₂₇H₃₆O₅
Molecular Weight:440.58
Hs Code.:

Synonyms:1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

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Chemical Property of 1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

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Technology Process of 1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

There total 3 articles about 1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 178432-52-5
1,10-bis(tetrahydropyranyloxy)-5-hydroxymethyl-2,8-decadiyne

: 108-95-2,27073-41-2
phenol

: 346700-28-5
1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; at 25 ℃; for 1h;
DOI:10.1021/jo0055842

Reference yield:

: 263720-92-9
1,10-dihydroxy-5-tert-butyldimethylsiloxymethyl-2,8-decadiyne

: 346700-28-5
1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 0 - 25 °C

2: 56.6 g / TBAF / tetrahydrofuran / 9 h

3: 80 percent / DEAD; PPh₃ / dimethylformamide / 1 h / 25 °C

With tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1021/jo0055842

Reference yield:

: tert-Butyl-dimethyl-{7-(tetrahydro-pyran-2-yloxy)-2-[4-(tetrahydro-pyran-2-yloxy)-but-2-ynyl]-hept-5-ynyloxy}-silane

: 346700-28-5
1,10-bis(tetrahydropyranyloxy)-5-phenoxymethyl-2,8-decadiyn

Guidance literature:: Multi-step reaction with 2 steps

1: 56.6 g / TBAF / tetrahydrofuran / 9 h

2: 80 percent / DEAD; PPh₃ / dimethylformamide / 1 h / 25 °C

With tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo0055842