N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

Base Information

Chemical Name:N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester
CAS No.:910116-98-2
Molecular Formula:C₃₀H₃₈N₂O₆
Molecular Weight:522.642
Hs Code.:

Synonyms:N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

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Chemical Property of N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

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Technology Process of N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

There total 1 articles about N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 21436-03-3
(S,S)-1,2-diaminocyclohexane

: 86507-74-6
3-(benzyloxy)-2,2-dimethyl-3-oxopropanoic acid

: 910116-98-2
N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; for 2h;
DOI:10.1021/jo060767v

Reference yield:

: 910116-98-2
N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

: N-[(1S,2S)-2-(2-Carboxy-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 24h;
DOI:10.1021/jo060767v

Reference yield:

: 910116-98-2
N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester

: 2-((S)-4-Isopropyl-4,5-dihydro-oxazol-2-yl)-N-{(1S,2S)-2-[2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-2-methyl-propionylamino]-cyclohexyl}-isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol / 24 h / 20 °C

2: 81 percent / HBTU; Et₃N / acetonitrile / 2 h

3: 37 percent / bis(2-methoxyethyl)aminosulfur trifluoride / tetrahydrofuran; CH₂Cl₂ / 5 h / -10 - 20 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo060767v