86507-74-6

Upstream product

• 57772-82-4 dibenzyl dimethylmalonate 
• 595-46-0 2,2-dimethylmalonic acid 
• 927389-10-4 2,2-dimethylmalonic acid benzyl tert-butyl ester 
• 100-51-6 benzyl alcohol 

Downstream Products

• 123963-80-4 tetrabutylammonium benzyl 2,2-dimethylmalonate 
• 813415-04-2 phenylmethyl 2-methyl-2-(2-propenyl)amidopropanoate 
• 910116-97-1 N-[(1R,2R)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester 
• 910116-98-2 N-[(1S,2S)-2-(2-Benzyloxycarbonyl-2-methyl-propionylamino)-cyclohexyl]-2,2-dimethyl-malonamic acid benzyl ester 
• 86507-75-7 2-chlorocarbonyl-2-methylpropionic acid benzyl ester 
• 813415-17-7 BnO-mAib-L-Ala-OH 
• 910117-00-9 N-((S)-1-Hydroxymethyl-2-methyl-propyl)-N'-{(1S,2S)-2-[2-((S)-1-hydroxymethyl-2-methyl-propylcarbamoyl)-2-methyl-propionylamino]-cyclohexyl}-2,2-dimethyl-malonamide 
• 910116-99-3 N-((S)-1-Hydroxymethyl-2-methyl-propyl)-N'-{(1R,2R)-2-[2-((S)-1-hydroxymethyl-2-methyl-propylcarbamoyl)-2-methyl-propionylamino]-cyclohexyl}-2,2-dimethyl-malonamide 
• 813415-16-6 BnO-mAib-L-Ala-OtBu 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The present invention features compounds that are prodrugs of HIIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

BICYCLO HETEROCYCLIC COMPOUND HAVING ANTIFUNGAL ACTION

It is intended to provide a 1,6-β-glucan synthase inhibitor which strongly inhibits proliferation and has a high safety. It is intended to provide a compound which can specifically or selectively expressing an antifungal action on a broad spectrum based on the action mechanism of inhibiting the synthesis of 1,6-β-glucan. Further, it is intended to provide a drug, in particular, an antifungal agent containing the above compound, its salt or a hydrate thereof. More specifically speaking, a compound represented by the following general formula (I), its salt or a hydrate thereof; and a drug or an antifungal agent containing the above compound, its salt or a hydrate thereof.

Total synthesis of sequential retro-peptide oligomers

The total synthesis of sequential oligomers of retro-peptides of the general formula Boc(-gGly-mAib)n-OBn, starting from dimethylmalonic acid, has been carried out in good overall yield. The key step is the formation of the gGly unit >N-CH

Orally effective acid prodrugs of the β-lactamase inhibitor sulbactam

Sulbactam (1) is a β-lactamase inhibitor with limited oral bioavailability. Lipophilic double-ester prodrug sulbactam pivoxil (2) significantly improves the oral absorption of sulbactam, as does the mutual prodrug double ester sultamicillin (3). We have found that double-ester prodrugs of sulbactam terminating in a carboxyl group (8) also were effective oral-delivery vehicles in rats. Carboxyl-terminated double esters have several potential advantages over their nonionizable lipophilic counterparts, including water solubility, crystallinity, choice of salts for dosage forms, and formation of innocuous byproducts on hydrolysis.