methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

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Chemical Name:methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate
CAS No.:474917-84-5
Molecular Formula:C₃₇H₅₁N₃O₁₂
Molecular Weight:729.825
Hs Code.:

Synonyms:methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

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Chemical Property of methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

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Technology Process of methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

There total 7 articles about methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474917-83-4
methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-{[2-(ethoxycarbonyl)butyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

: 4755-77-5
Ethyl oxalyl chloride

: 474917-84-5
methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 36873-42-4
ethyl 2-formylbutanoate

: 474917-84-5
methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane

2: iPrNEt₂ / CH₂Cl₂

3: H₂ / Pd/C

With N,N-diethyl-N-isopropylamine; hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00725-X

Reference yield:

: 55533-24-9,164332-89-2
L-N-tert-butoxycarbonyl-p-aminophenylalanine

: 474917-84-5
methyl 2-{4-[(N-(tert-butoxycarbonyl)-4-[{2-(ethoxycarbonyl)butyl][ethoxy(oxo)acetyl]amino}-L-phenylalanyl)amino]butoxy}-6-hydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: TBTU / dimethylformamide

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: iPrNEt₂ / CH₂Cl₂

4: H₂ / Pd/C

With N,N-diethyl-N-isopropylamine; hydrogen; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00725-X