R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE

Base Information

• Chemical Name: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE
• CAS No.: 67412-96-8
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2906190090

Synonyms:D-p-methoxyphenylglycine amide;PS-J-111;

Chemical Property of R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 371.171°C at 760 mmHg
• Flash Point: 206.098°C
• PSA: 78.34000
• Density: 1.19g/cm³
• LogP: 1.58090
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-AMINO-2-(4-METHOXYPHENYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE

There total 5 articles about R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-amino-2-(4-methoxyphenyl)acetonitrile (42456-26-8) → (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (24593-48-4,19789-59-4) + D-(-)-4-methoxyphenylglycine amide (67412-96-8)

Guidance literature:

With potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; In water; at 30 ℃; for 1.5h; pH=7.62;

DOI:10.1021/jo0256282

Reference yield:

2-amino-2-(4-methoxyphenyl)acetamide (76986-15-7) → (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (24593-48-4,19789-59-4) + D-(-)-2-(4-methoxyphenyl)glycine (24593-49-5,19789-59-4) + D-(-)-4-methoxyphenylglycine amide (67412-96-8)

Guidance literature:

With potassium phosphatr buffer; Rhodococcus sp.AJ₂₇₀ cells; at 30 ℃; for 2h; pH=7.0; Enzymatic reaction;

DOI:10.1021/jo0256282

Reference yield:

[(R)-Carbamoyl-(4-methoxy-phenyl)-methyl]-carbamic acid benzyl ester → D-(-)-4-methoxyphenylglycine amide (67412-96-8)

Guidance literature:

With hydrogen; palladium dihydroxide;

DOI:10.1016/j.bmcl.2004.04.074

upstream raw materials:

2-amino-2-(4-methoxyphenyl)acetamide

2-amino-2-(4-methoxyphenyl)acetonitrile

(R)-(N-benzyloxycarbonyl)-p-methoxyphenylglycine

Downstream raw materials:

2-(R)-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)acetylamino]-acetamide

Refernces

Synthesis of (S)-α-cyclopropyl-4-phosphonophenylglycine

10.1021/jo0013711

The research focuses on the asymmetric synthesis of (S)-CPPG, a selective antagonist for group III metabotropic glutamate receptors (mGluRs), which are important in studying neurotransmission mechanisms. The synthesis begins with (R)-4-benzoxyphenylglycine and involves several steps including protection of the amino group, formation of trans-oxazolidinone, introduction of a dicarbon functional group, and cyclopropanation. Key reactants include methyl chloroformate, benzaldehyde dimethyl acetal, boron trifluoride etherate, and various catalysts for cyclopropanation. The process involves recrystallization, HPLC, and 1H NMR for analysis, and culminates in the production of (S)-CPPG with a final yield of 99% after purification. The study also mentions the biological evaluation of the synthesized compound, indicating ongoing research into its physiological effects.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 67412-96-8 R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send