N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Base Information

• Chemical Name: N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine
• CAS No.: 1125587-31-6
• Molecular Formula: C₄₁H₄₃N₇O₆
• Molecular Weight: 729.836

Synonyms:N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property of N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property:

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Technology Process of N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

There total 1 articles about N₂-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N2-formamidino-8N-(4-methylphenylamino)-2'-deoxyguanosine (1125587-06-5) + 4,4'-dimethoxytrityl chloride (40615-36-9) → N2-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1125587-31-6)

Guidance literature:

In pyridine; at 20 ℃; for 5h;

DOI:10.1002/chem.200800979

Reference yield: 68.0%

N2-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (1125587-31-6) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → N2-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosin-3'-yl-β-cyanoethyl-N,N'-diisopropylphosphoramidite (1125587-64-5)

Guidance literature:

With 4,5-dicyano-1H-imidazole; In dichloromethane; acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.200800979

upstream raw materials:

N₂-formamidino-8N-(4-methylphenylamino)-2'-deoxyguanosine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

N2-formamidino-8N-(4-methylphenylamino)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosin-3'-yl-β-cyanoethyl-N,N'-diisopropylphosphoramidite

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