6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

Base Information

Chemical Name:6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one
CAS No.:73367-82-5
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

Synonyms:6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

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Chemical Property of 6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

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Technology Process of 6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

There total 9 articles about 6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 85203-10-7
6-(3-chloropropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

: 73367-82-5
6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1021/ja00348a051

Reference yield:

: 85203-07-2
3-(N-benzylanilino)-6-ethylcyclohex-2-en-1-one

: 73367-82-5
6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium diisopropylamide / 1.) THF, hexane, HMPA, -78 deg C, 7 h, 2.) -78 deg C, 5 h, room temperature, 15 h

2: 63 percent / hydrogen / 5percent palladium on carbon / acetic acid; ethanol / 15 h / 1810.02 Torr

3: 100 percent / n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h

4: 90 percent / sodium azide / dimethylformamide / 12 h / 80 °C

With n-butyllithium; sodium azide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00348a051

Reference yield:

: 85203-06-1
3-(benzyl(phenyl)amino)cyclohex-2-en-1-one

: 73367-82-5
6-(3-azidopropyl)-6-ethyl-3-(N-(methoxycarbonyl)anilino)cyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) lithium diisopropylamide / 1.) THF, hexane, HMPA, -78 deg C, 2.5 h, 2.) -78 deg C, 5 h, room temperature, 15 h

2: 1.) lithium diisopropylamide / 1.) THF, hexane, HMPA, -78 deg C, 7 h, 2.) -78 deg C, 5 h, room temperature, 15 h

3: 63 percent / hydrogen / 5percent palladium on carbon / acetic acid; ethanol / 15 h / 1810.02 Torr

4: 100 percent / n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h

5: 90 percent / sodium azide / dimethylformamide / 12 h / 80 °C

With n-butyllithium; sodium azide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/ja00348a051