5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

Base Information

Chemical Name:5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole
CAS No.:1415991-86-4
Molecular Formula:C₂₅H₂₆FN₅O₂S
Molecular Weight:479.578
Hs Code.:

Synonyms:5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

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Chemical Property of 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

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Technology Process of 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

There total 7 articles about 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(piperidin-4-yl)-1H-benzo[d]imidazole 2,2,2-trifluoroacetate

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1415991-86-4
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; for 12h;

Reference yield:

: 142994-04-5
2-fluoro-4-(methylsulphonyl)benzoic acid

: 1415991-86-4
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyphosphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: Dichlorofluoromethane / 3 h / 25 - 28 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 90 °C

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; Dichlorofluoromethane; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki Coupling;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1415991-86-4
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyphosphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: Dichlorofluoromethane / 3 h / 25 - 28 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 90 °C

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; Dichlorofluoromethane; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki Coupling;