2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

Base Information

Chemical Name:2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride
CAS No.:1188335-82-1
Molecular Formula:C₃₂H₃₃NO₄*ClH
Molecular Weight:532.079
Hs Code.:

Synonyms:2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

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Chemical Property of 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

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Technology Process of 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

There total 6 articles about 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1188335-64-9
2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid

: 1188335-82-1
2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; at 20 ℃;
DOI:10.1021/ol901999f

Reference yield:

: 1188335-69-4
ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

: 1188335-82-1
2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

Guidance literature:: ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate; With sodium hydroxide; at 40 ℃;

With hydrogenchloride; In water; at 20 ℃;
DOI:10.1016/j.bmcl.2012.09.007

Reference yield:

: 28994-41-4
o-Benzylphenol

: 1188335-82-1
2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra-N-butylammonium tribromide / chloroform / 20 °C

2.1: sodium hydride / tetrahydrofuran / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / Reflux

4.1: potassium carbonate / acetone / Reflux

5.1: sodium hydroxide / 40 °C

5.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetra-N-butylammonium tribromide; sodium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; chloroform; water; acetone; 2.1: |Williamson Ether Synthesis / 3.1: |Suzuki Coupling / 4.1: |Williamson Ether Synthesis;
DOI:10.1016/j.bmcl.2012.09.007