ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

Base Information

Chemical Name:ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate
CAS No.:1188335-69-4
Molecular Formula:C₃₄H₃₇NO₄
Molecular Weight:523.672
Hs Code.:

Synonyms:ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

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Chemical Property of ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

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Technology Process of ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

There total 4 articles about ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1188335-73-0
ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-ol-4-oxy)acetate

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1188335-69-4
ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

Guidance literature:: With potassium carbonate; In acetone; Reflux;
DOI:10.1021/ol901999f

Reference yield:

: 28994-41-4
o-Benzylphenol

: 1188335-69-4
ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: tetra-N-butylammonium tribromide / chloroform / 20 °C

2: sodium hydride / tetrahydrofuran / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / Reflux

4: potassium carbonate / acetone / Reflux

With bis-triphenylphosphine-palladium(II) chloride; tetra-N-butylammonium tribromide; sodium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; chloroform; water; acetone; 2: |Williamson Ether Synthesis / 3: |Suzuki Coupling / 4: |Williamson Ether Synthesis;
DOI:10.1016/j.bmcl.2012.09.007

Reference yield:

: 1188335-74-1
2-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1188335-69-4
ethyl 2-(1,1'-biphenyl-3,3'-dibenzyl-4'-[2-(dimethylamino)ethoxy]-4-oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triphenylphosphine / tetrahydrofuran; water / Reflux

2: potassium carbonate / acetone / Reflux

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; water; acetone; 1: |Suzuki Coupling / 2: |Williamson Ether Synthesis;
DOI:10.1016/j.bmcl.2012.09.007