1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Base Information

Chemical Name:1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide
CAS No.:103343-79-9
Molecular Formula:C₂₅H₂₁FN₄O
Molecular Weight:412.466
Hs Code.:

Synonyms:1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

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Chemical Property of 1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

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Technology Process of 1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

There total 5 articles about 1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 58881-45-1
Indole-2-carbonyl chloride

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

: 103343-79-9
1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 23 ℃;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-37-9
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

: 103343-79-9
1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

2: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

3: 50 percent / W-2 Raney nickel / ethanol / 50 h

4: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

5: 90 percent / triethylamine / tetrahydrofuran / 0 - 23 °C

With Lawessons reagent; dmap; hydrogen bromide; triethylamine; W-2 Raney nickel; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-76-6
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-<<(benzyloxy)carbonyl>methyl>-2H-1,4-benzodiazepin-2-thione

: 103343-79-9
1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / W-2 Raney nickel / ethanol / 50 h

2: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

3: 90 percent / triethylamine / tetrahydrofuran / 0 - 23 °C

With hydrogen bromide; triethylamine; W-2 Raney nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00163a069