1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Base Information

Chemical Name:1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine
CAS No.:123903-97-9
Molecular Formula:C₁₆H₁₆FN₃
Molecular Weight:269.322
Hs Code.:

Synonyms:1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

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Chemical Property of 1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

There total 3 articles about 1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103343-75-5
1,3-dihydro-3(R,S)-<<(benzyloxy)carbonyl>methyl>-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Guidance literature:: With hydrogen bromide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-37-9
1,3-dihydro-5-(2'-fluorophenyl)-3(R,S)-(aminomethyl)-2H-1,4-benzodiazepin-2-one

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

2: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

3: 50 percent / W-2 Raney nickel / ethanol / 50 h

4: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

With Lawessons reagent; dmap; hydrogen bromide; W-2 Raney nickel; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069

Reference yield:

: 103343-35-7
N-(2'-Fluorobenzoylphenyl)-2,3-diphthalylaminopropionylamide

: 123903-97-9
1,3-dihydro-3(R,S)-(aminomethyl)-5-(2'-fluorophenyl)-2H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / hydrazine / methanol / 14 h / 23 °C

2: 97 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 23 °C / overnight

3: 95 percent / Lawesson's reagent / toluene / 1.5 h / Heating

4: 50 percent / W-2 Raney nickel / ethanol / 50 h

5: hydrogen bromide / CH₂Cl₂ / 0 - 20 °C

With Lawessons reagent; dmap; hydrogen bromide; hydrazine; W-2 Raney nickel; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00163a069