sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

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Chemical Name:sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate
CAS No.:1431299-94-3
Molecular Formula:C₂₂H₁₈FN₄O₃S*Na
Molecular Weight:460.464
Hs Code.:

Synonyms:sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

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Chemical Property of sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

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Technology Process of sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

There total 8 articles about sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

: 1431300-73-0
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

: 1431299-94-3
sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1431299-94-3
sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere; Reflux

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

4: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;

Reference yield:

: 1431300-95-6
2,2-dimethyl-3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)oxy)propanoic acid methyl ester

: 1431299-94-3
sodium 3-((5-(4-((4-fluorobenzo[d]thiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

2: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

3: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;