3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

Base Information

Chemical Name:3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid
CAS No.:1431300-73-0
Molecular Formula:C₂₂H₁₉FN₄O₃S
Molecular Weight:438.482
Hs Code.:

Synonyms:3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

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Chemical Property of 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

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Technology Process of 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

There total 7 articles about 3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.9%

: 1431300-98-9
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid methyl ester

: 1431300-73-0
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 18 - 25 ℃; for 3h;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1431300-73-0
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere; Reflux

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;

Reference yield:

: 1431300-95-6
2,2-dimethyl-3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)oxy)propanoic acid methyl ester

: 1431300-73-0
3-((5-(4-((4-fluorobenzothiazol-2-yl)amino)phenyl)pyrimidin-2-yl)oxy)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

2: water; sodium hydroxide / methanol / 3 h / 18 - 25 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; water; 1: |Suzuki Coupling;