Technology Process of 2-[(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol
There total 13 articles about 2-[(6-{3-[(2,6-dichlorobenzyl)(methyl)amino]propoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
TBAF on silica gel;
In
tetrahydrofuran;
at 20 ℃;
for 19h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydroxide / tetrabutylammomium bromide / water / 20 h / 20 °C
2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C
3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr
4: triethylamine / dichloromethane / 20 °C
5: N-ethyl-N,N-diisopropylamine / 18 h / 45 °C
6: hydrazine / ethanol / 100 h / 20 °C
7: potassium carbonate / 1,4-dioxane / 20 h / 105 °C
8: TBAF on silica gel / tetrahydrofuran / 19 h / 20 °C
With
sodium hydroxide; TBAF on silica gel; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C
2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr
3: triethylamine / dichloromethane / 20 °C
4: N-ethyl-N,N-diisopropylamine / 18 h / 45 °C
5: hydrazine / ethanol / 100 h / 20 °C
6: potassium carbonate / 1,4-dioxane / 20 h / 105 °C
7: TBAF on silica gel / tetrahydrofuran / 19 h / 20 °C
With
TBAF on silica gel; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
palladium 10% on activated carbon; cetyltributylphosphonium bromide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
