{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

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Chemical Name:{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid
CAS No.:432551-01-4
Molecular Formula:C₃₃H₄₁N₃O₉
Molecular Weight:623.703
Hs Code.:

Synonyms:{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

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Chemical Property of {5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

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Technology Process of {5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

There total 3 articles about {5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 292835-95-1
ethyl 3-[5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)phenyl]-2-propynoate

: 432551-01-4
{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4.5h;
DOI:10.1021/jm011100y

Reference yield:

: 292835-93-9
methyl 2-{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-iodophenoxy}acetate

: 432551-01-4
{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / Cu₂O / dimethylformamide / 16 h / 110 °C

2: TFA / CH₂Cl₂ / 4 h / 0 - 20 °C

3: 1.09 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

4: 99 percent / 2.5 M aq. LiOH / tetrahydrofuran / 4.5 h / 20 °C

With copper(I) oxide; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011100y

Reference yield:

: [5-((S)-2-Amino-2-pentylcarbamoyl-ethyl)-2-methoxycarbonylmethoxy-phenyl]-propynoic acid ethyl ester

: 432551-01-4
{5-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-pentylcarbamoyl-ethyl]-2-carboxymethoxy-phenyl}-propynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.09 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

2: 99 percent / 2.5 M aq. LiOH / tetrahydrofuran / 4.5 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm011100y