(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

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Chemical Name:(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol
CAS No.:185761-27-7
Molecular Formula:C₁₈H₁₉ClN₂O
Molecular Weight:314.815
Hs Code.:

Synonyms:(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

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Chemical Property of (R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

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Technology Process of (R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

There total 5 articles about (R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 185761-24-4
(R)-2-(4-Chloro-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

: 185761-27-7
(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

: 2-(4-Chloro-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propan-1-ol

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; water; for 0.416667h; Ambient temperature;
DOI:10.1016/S0040-4020(96)00946-5

Reference yield:

: 35086-79-4,95602-71-4
cinnamoyl chloride

: 185761-27-7
(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. Na₂CO₃ / CH₂Cl₂ / Ambient temperature

2: 87 percent / POCl₃ / toluene / Ambient temperature

3: CH₂Cl₂; toluene / 46 h / Ambient temperature

4: 80 percent / NiCl₂*6H₂O, NaBH₄ / tetrahydrofuran; H₂O / 0.42 h / Ambient temperature

With sodium tetrahydroborate; sodium carbonate; nickel dichloride; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(96)00946-5

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 185761-27-7
(R)-2-[(R)-4-(4-Chloro-phenyl)-4,5-dihydro-3H-pyrrol-2-ylamino]-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. Na₂CO₃ / CH₂Cl₂ / Ambient temperature

2: 87 percent / POCl₃ / toluene / Ambient temperature

3: CH₂Cl₂; toluene / 46 h / Ambient temperature

4: 80 percent / NiCl₂*6H₂O, NaBH₄ / tetrahydrofuran; H₂O / 0.42 h / Ambient temperature

With sodium tetrahydroborate; sodium carbonate; nickel dichloride; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(96)00946-5