C₇₁H₆₈N₆O₁₁

Base Information

Chemical Name:C₇₁H₆₈N₆O₁₁
CAS No.:271581-43-2
Molecular Formula:C₇₁H₆₈N₆O₁₁
Molecular Weight:1181.35
Hs Code.:

C<sub>71</sub>H<sub>68</sub>N<sub>6</sub>O<sub>11</sub>

Synonyms:C₇₁H₆₈N₆O₁₁

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Chemical Property of C₇₁H₆₈N₆O₁₁

Chemical Property:

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Technology Process of C₇₁H₆₈N₆O₁₁

There total 14 articles about C₇₁H₆₈N₆O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 271581-33-0
C₇₁H₇₂N₆O₁₁

: 271581-43-2
C₇₁H₆₈N₆O₁₁

Guidance literature:: C₇₁H₇₂N₆O₁₁; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃;

With hexachloroethane; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃;
DOI:10.1002/(SICI)1521-3773(20000303)39:5<937::AID-ANIE937>3.0.CO;2-A

Reference yield:

: 218769-48-3
(S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 271581-43-2
C₇₁H₆₈N₆O₁₁

Guidance literature:: Multi-step reaction with 12 steps

1.1: 89 percent / TBTU; DIPEA / dimethylformamide / 20 °C

2.1: 69 percent / 2-(di-tert-butylphosphanyl)biphenyl; Ag₃PO₄ / Pd₂(dba)3 / tetrahydrofuran / 90 °C

3.1: 97 percent / DEAD; PPh₃ / tetrahydrofuran

4.1: aq. OsO₄; DMAP / 2-methyl-propan-2-ol / 20 °C

4.2: H₂S / tetrahydrofuran / -50 °C

5.1: 90 percent / p-TsOH / toluene / 1 h / 95 °C

6.1: TBTU; DIPEA / dimethylformamide

7.1: p-TsOH / 95 °C

8.1: 85 percent / NaBH₄ / methanol; tetrahydrofuran / -10 °C

9.1: 81 percent / (+)-10-camphorsulfonic acid / benzene / 6.5 h / 60 °C

10.1: AlMe₃

10.2: 88 percent / toluene; CH₂Cl₂ / 20 °C

11.1: 95 percent / pyridine / CH₂Cl₂ / 0 °C

12.1: aq. DDQ / tetrahydrofuran / 20 °C

12.2: PPh₃; Et₃N; (CCl₃)2 / CH₂Cl₂ / 20 °C

With pyridine; dmap; sodium tetrahydroborate; osmium(VIII) oxide; silver orthophosphate; trimethylaluminum; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; (+)-10-camphorsulfonic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; johnphos; diethylazodicarboxylate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene; 1.1: Acylation / 2.1: Dehydroiodination / 3.1: Etherification / 4.1: Oxidation / 4.2: Substitution / 5.1: Hydrolysis / 6.1: Acylation / 7.1: Rearrangement / 8.1: Reduction / 9.1: Cyclization / 10.1: Metallation / 10.2: Acylation / 11.1: Acetylation / 12.1: Oxidation / 12.2: Dehydration;
DOI:10.1002/(SICI)1521-3773(20000303)39:5<937::AID-ANIE937>3.0.CO;2-A

Reference yield:

: 218769-34-7
[(S)-2-(4-Benzyloxy-3-iodo-phenyl)-1-((S)-1-{4-cyano-5-[1-(2-hydroxy-phenyl)-vinyl]-oxazol-2-yl}-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 271581-43-2
C₇₁H₆₈N₆O₁₁

Guidance literature:: Multi-step reaction with 11 steps

1.1: 69 percent / 2-(di-tert-butylphosphanyl)biphenyl; Ag₃PO₄ / Pd₂(dba)3 / tetrahydrofuran / 90 °C

2.1: 97 percent / DEAD; PPh₃ / tetrahydrofuran

3.1: aq. OsO₄; DMAP / 2-methyl-propan-2-ol / 20 °C

3.2: H₂S / tetrahydrofuran / -50 °C

4.1: 90 percent / p-TsOH / toluene / 1 h / 95 °C

5.1: TBTU; DIPEA / dimethylformamide

6.1: p-TsOH / 95 °C

7.1: 85 percent / NaBH₄ / methanol; tetrahydrofuran / -10 °C

8.1: 81 percent / (+)-10-camphorsulfonic acid / benzene / 6.5 h / 60 °C

9.1: AlMe₃

9.2: 88 percent / toluene; CH₂Cl₂ / 20 °C

10.1: 95 percent / pyridine / CH₂Cl₂ / 0 °C

11.1: aq. DDQ / tetrahydrofuran / 20 °C

11.2: PPh₃; Et₃N; (CCl₃)2 / CH₂Cl₂ / 20 °C

With pyridine; dmap; sodium tetrahydroborate; osmium(VIII) oxide; silver orthophosphate; trimethylaluminum; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; (+)-10-camphorsulfonic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; johnphos; diethylazodicarboxylate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene; 1.1: Dehydroiodination / 2.1: Etherification / 3.1: Oxidation / 3.2: Substitution / 4.1: Hydrolysis / 5.1: Acylation / 6.1: Rearrangement / 7.1: Reduction / 8.1: Cyclization / 9.1: Metallation / 9.2: Acylation / 10.1: Acetylation / 11.1: Oxidation / 11.2: Dehydration;
DOI:10.1002/(SICI)1521-3773(20000303)39:5<937::AID-ANIE937>3.0.CO;2-A