N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine

Base Information

Chemical Name:N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine
CAS No.:218769-48-3
Molecular Formula:C21H24INO5
Molecular Weight:497.33
Hs Code.:
DSSTox Substance ID:DTXSID70446274
Nikkaji Number:J1.295.527H
Wikidata:Q82264885
Mol file:218769-48-3.mol

Synonyms:218769-48-3;N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine;SCHEMBL13866652;DTXSID70446274;(2S)-3-(3-iodo-4-phenylmethoxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

Suppliers and Price of N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:497.06992
Heavy Atom Count:28
Complexity:515

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC(=C(C=C1)OCC2=CC=CC=C2)I)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC(=C(C=C1)OCC2=CC=CC=C2)I)C(=O)O

Technology Process of N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine

There total 8 articles about N-(tert-Butoxycarbonyl)-O-benzyl-3-iodotyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 691394-91-9
methyl (S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

: 218769-48-3
(S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b00894

Reference yield:

: 100-39-0
benzyl bromide

: 71400-63-0,478183-68-5
N-tert-butyloxycarbonyl-3-iodo-L-tyrosine

: 218769-48-3
(S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: N-tert-butyloxycarbonyl-3-iodo-L-tyrosine; With sodium methylate; In methanol; for 0.166667h; Inert atmosphere;

benzyl bromide; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.04.023

Reference yield:

: 70-78-0
3-Iodo-L-tyrosine

: 218769-48-3
(S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: CuNO₃; NaOH

With sodium hydroxide; cuprous nitrate;
DOI:10.1002/1521-3773(20011217)40:24<4765::AID-ANIE4765>3.0.CO;2-1