methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Base Information

Chemical Name:methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS No.:1276687-35-4
Molecular Formula:C₂₂H₁₇F₃N₂O₃S
Molecular Weight:446.45
Hs Code.:

Synonyms:methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

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Chemical Property of methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

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Technology Process of methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

There total 4 articles about methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1276687-31-0
methyl (+/-)-5-(2-nitrophenylamino)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 149-73-5
trimethyl orthoformate

: 1276687-35-4
methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: With hydrogen; pyridinium p-toluenesulfonate; In ethyl acetate; at 20 ℃;
DOI:10.1021/jm1011726

Reference yield:

: 5118-06-9
methyl 3-hydroxy-2-thiophenecarboxylate

: 1276687-35-4
methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 3 h / -10 - 0 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 0 - 20 °C

3: iron; acetic acid / 2 h / 65 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 50 °C

5: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; sulfuric acid; hydrogen; nitric acid; pyridinium p-toluenesulfonate; iron; caesium carbonate; acetic acid; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; ethyl acetate; 2: Mitsunobu reaction / 4: Buchwald-Hartwig reaction;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-27-4
methyl (+/-)-5-amino-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

: 1276687-35-4
methyl (+/-)-5-(1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 50 °C

2: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethyl acetate; 1: Buchwald-Hartwig reaction;
DOI:10.1021/jm1011726