Technology Process of (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride
There total 24 articles about (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
Ambient temperature;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 81 percent / Na2CO3 / H2O / 5 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd-C / methanol / Ambient temperature
3: 68 percent / DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
4: 7.8 g / K2CO3,KI / dimethylformamide / Ambient temperature
5: 99 percent / N2H2*H2O / ethanol / 1 h / Heating
6: 0.74 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
7: 5 N HCl / ethyl acetate / Ambient temperature
With
hydrogenchloride; 4 A molecular sieve; diazene; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 81 percent / Na2CO3 / H2O / 5 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd-C / methanol / Ambient temperature
3: 68 percent / DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
4: 7.8 g / K2CO3,KI / dimethylformamide / Ambient temperature
5: 99 percent / N2H2*H2O / ethanol / 1 h / Heating
6: 7 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
7: 67 percent / 5 N HCl / ethyl acetate / Ambient temperature
With
hydrogenchloride; 4 A molecular sieve; diazene; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128