(S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Base Information

Chemical Name:(S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride
CAS No.:103584-46-9
Molecular Formula:C₂₄H₃₄N₂O₅S*ClH
Molecular Weight:499.071
Hs Code.:

Synonyms:(S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Suppliers and Price of (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

There total 24 articles about (S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 103604-00-8
tert-butyl (R)-3-<(S)-1-ethoxycarbonyl-3-cyclohexylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-α-methylacetate

: 103584-46-9
(S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 103584-46-9
(R)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

3: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

4: 7.8 g / K₂CO₃,KI / dimethylformamide / Ambient temperature

5: 99 percent / N₂H₂*H₂O / ethanol / 1 h / Heating

6: 0.74 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

7: 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; diazene; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 60115-45-9
S-(o-nitrophenyl)-L-cysteine

: 103584-46-9
(S)-2-[(R)-5-(1-Carboxy-ethyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino]-4-cyclohexyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd-C / methanol / Ambient temperature

3: 68 percent / DEPC, Et₃N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.

4: 7.8 g / K₂CO₃,KI / dimethylformamide / Ambient temperature

5: 99 percent / N₂H₂*H₂O / ethanol / 1 h / Heating

6: 7 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

7: 67 percent / 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; diazene; hydrogen; sodium cyanoborohydride; sodium carbonate; potassium carbonate; triethylamine; diethyl dicarbonate; potassium iodide; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128