tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

Base Information

Chemical Name:tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate
CAS No.:1380671-58-8
Molecular Formula:C₂₆H₂₈Cl₂F₃NO₄
Molecular Weight:546.414
Hs Code.:

Synonyms:tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

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Chemical Property of tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

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Technology Process of tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

There total 5 articles about tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: 1380671-54-4
tert-Butyl 1-[(3-amino-4-chlorophenyl)(hydroxy)methyl]cyclopropanecarboxylate

: 1380671-58-8
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380671-58-8
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

With pyridine; n-butyllithium; hydrogen; diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 16588-34-4
4-chloro-3-nitro-benzaldehyde

: 1380671-58-8
tert-Butyl 1-[(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-phenyl)(hydroxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 72 h / 760.05 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

With pyridine; n-butyllithium; hydrogen; diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide;