4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Base Information

Chemical Name:4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester
CAS No.:221690-27-3
Molecular Formula:C₃₂H₃₇NO₄
Molecular Weight:499.65
Hs Code.:

4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9<i>H</i>-fluoren-9-ylamino)-octanoic acid <i>tert</i>-butyl ester

Synonyms:4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

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Technology Process of 4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

There total 2 articles about 4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 563-80-4
3-methyl-butan-2-one

: 215182-76-6
tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate

: 221690-27-3
4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/jo982181h

Reference yield:

: 120230-41-3
N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

: 221690-27-3
4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / DIBAL-H / toluene / 0.42 h / -78 °C

2: 77 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 °C

With n-butyllithium; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo982181h

Reference yield: 87.0%

: 221690-27-3
4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

: 221690-42-2
7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; 1.) 0 deg C, 30 min, 2.) room temp.;
DOI:10.1021/jo982181h