(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt

Base Information

• Chemical Name: (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt
• CAS No.: 102916-46-1
• Molecular Formula: C8H13NO3^.C8H11N
• Molecular Weight: 292.378
• Hs Code.: 2933790090
• Mol file: 102916-46-1.mol

Synonyms:(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid,(R)-methyl benzylamine salt;

Chemical Property of (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt

Chemical Property:

• PSA: 83.63000
• LogP: 2.81650

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-Phenylethanamine(S)-2-(2-oxopyrrolidin-1-yl)butanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt

There total 3 articles about (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetic acid (R)-alpha-methylbenzenemethanamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

(R)-1-phenyl-ethyl-amine (3886-69-9) + α-ethyl-2-oxo-1-pyrrolidineacetic acid, (67118-31-4) → (S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt (102916-46-1)

Guidance literature:

With triethylamine; In toluene; at 80 - 90 ℃;

Reference yield: 41.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + α-ethyl-2-oxo-1-pyrrolidineacetic acid, (67118-31-4) → C8H11N*C8H13NO3 + (S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt (102916-46-1)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 3h; Purification / work up; Heating / reflux; Resolution of racemate;

Reference yield:

ethyl 2-(2-oxo-1-pyrrolidinyl)butyrate (86815-10-3) → (S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt (102916-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 3 h / 60 °C

2: triethylamine / toluene / 80 - 90 °C

With water; triethylamine; sodium hydroxide; In toluene;

upstream raw materials:

(R)-1-phenyl-ethyl-amine

α-ethyl-2-oxo-1-pyrrolidineacetic acid,

ethyl 2-(2-oxo-1-pyrrolidinyl)butyrate

Downstream raw materials:

levetiracetam

(R)-2-pyrrolidone-N-butyric acid

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid

Refernces

• 1、 -. "IMPROVED PROCESS FOR THE PREPARATION OF (S)-ALPHA-ETYL-2-OXO-1-PYRROLIDINEACETAMIDE AND (R)-ALPHA-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE". Page/Page column 13. . Retrieved 2008/06/13.