methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

Base Information

Chemical Name:methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate
CAS No.:134164-11-7
Molecular Formula:C₂₃H₃₁ClN₂O₄S
Molecular Weight:467.029
Hs Code.:

Synonyms:methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

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Chemical Property of methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

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Technology Process of methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

There total 21 articles about methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 144409-93-8
methyl 8-<<(4-chlorophenyl)sulfonyl>amino>-4-<3-(3-pyridinyl)propyl>oct-2-enoate

: 134164-11-7
methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

Guidance literature:: With sodium tetrahydroborate; cobalt(II) chloride; for 1h; Ambient temperature;
DOI:10.1021/jm00101a015

Reference yield:

: 8-(4-Chloro-benzenesulfonylamino)-4-((Z)-3-pyridin-3-yl-allyl)-octanoic acid methyl ester

: 134164-11-7
methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 760 Torr;
DOI:10.1021/jm00101a015

Reference yield:

: 144385-72-8
5-(4-Amino-butyl)-oxepan-2-one

: 134164-11-7
methyl 8-(p-chlorophenylsulfonamido)-4-[3-(pyridin-3-yl)propyl]-octanoate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: 1N aq. NaOH / methanol / 18 h

3: SOCl₂ / 2.5 h

4: (COCl)2, Et₃N / CH₂Cl₂ / 0.25 h / -60 °C

5: 1.) t-BuOK / 1.) THF, RT, 1 h, 2.) THF, 18 h

6: H₂ / 10percent Pd/C / ethanol / 18 h / 760 Torr

With dmap; sodium hydroxide; thionyl chloride; oxalyl dichloride; potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00101a015