Sodium danshensu

Base Information

• Chemical Name: Sodium danshensu
• CAS No.: 67920-52-9
• Molecular Formula: C₉H₉O₅*Na
• Molecular Weight: 220.157
• Hs Code.: 29329990
• Mol file: 67920-52-9.mol

Synonyms:Benzenepropanoicacid, a,3,4-trihydroxy-, monosodium salt(9CI);Benzenepropanoic acid, a,3,4-trihydroxy-, monosodium salt, (?à)-;3,4-Dihydroxyphenyl-a-hydroxypropanoic acid sodium salt;Sodium DL-b-(3,4-dihydroxyphenyl)lactate;Sodium Danshensu;

Chemical Property of Sodium danshensu

Chemical Property:

• PSA: 100.82000
• LogP: -1.24890
• Storage Temp.: 2-8°C

Purity/Quality:

≥98% ^*data from raw suppliers

Sodium Danshensu ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.
• Uses: Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

Technology Process of Sodium danshensu

There total 9 articles about Sodium danshensu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-β-(3-acetyl-4-hydroxy)phenyl-α-hydroxypropionic acid → sodium (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (67810-33-7,67920-52-9,81075-52-7)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 40 ℃; for 0.5h;

Reference yield:

(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionic acid ethyl ester → sodium (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (67810-33-7,67920-52-9,81075-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water / 3 h / Reflux

2: aluminum (III) chloride / nitrobenzene / 6 h / 25 - 100 °C

3: sodium nitrite / water / 24 h / 20 °C

4: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 40 °C

With hydrogenchloride; aluminum (III) chloride; dihydrogen peroxide; sodium hydroxide; sodium nitrite; In water; nitrobenzene;

Reference yield:

methyl (R)-2-acetamido-3-(4-acetoxyphenyl)propanoate → sodium (R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (67810-33-7,67920-52-9,81075-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water / 3 h / Reflux

2: aluminum (III) chloride / nitrobenzene / 6 h / 25 - 100 °C

3: sodium nitrite / water / 24 h / 20 °C

4: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 40 °C

With hydrogenchloride; aluminum (III) chloride; dihydrogen peroxide; sodium hydroxide; sodium nitrite; In water; nitrobenzene;

upstream raw materials:

tyrosine

α-acetylamino-4-hydroxy-cinnamic acid

(Z)-3-(4-Acetoxy-phenyl)-2-acetylamino-acrylic acid methyl ester

Ac-D-Tyrosine

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