(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Base Information

Chemical Name:(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal
CAS No.:113453-37-5
Molecular Formula:C₂₅H₄₂O₄Si
Molecular Weight:434.692
Hs Code.:

Synonyms:(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Suppliers and Price of (2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

There total 13 articles about (2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 113453-36-4
(2S,3R,4Z,8S)-N-methoxy-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-N,2,8-trimethyl-3-<(phenylmethoxy)methoxy>-4-noneamide

: 113453-37-5
(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; -78 deg C, 30 min; -78 - -50 deg C, 30 min;
DOI:10.1021/ja00216a026

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 113453-37-5
(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / i-Pr₂EtN, Bu₄NI / tetrahydrofuran / 38 h / Ambient temperature

2: 1) O₃, Sudan III indicator, 2) Me₂S / 1) metanol, pyridine, -78 deg C; 2) room temp. 4 h

3: 83 percent / toluene / -78 - -20 deg C, 45 min; 0 deg C, 30 min; 0 deg C - RT, 15 min

4: 97 percent / DIBAL / toluene; tetrahydrofuran / -78 deg C, 30 min; -78 - -50 deg C, 30 min

With dimethylsulfide; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; ozone; N-ethyl-N,N-diisopropylamine; Sudan III; In tetrahydrofuran; toluene;
DOI:10.1021/ja00216a026

Reference yield:

: 5673-98-3,63501-27-9,88080-30-2,63501-26-8
(S)-(-)-2-methyl-4-penten-1-ol

: 113453-37-5
(2S,3R,4Z,8S)-2,8-dimethyl-9-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-<(phenylmethoxy)methoxy>-4-nonenal

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 25 °C

2: 1) Cp₂ZrHCl, 2) I₂ / 1) benzene, 25 deg C, 9 h

3: 83 percent / i-Pr₂EtN / acetonitrile / 14 h / 50 °C

4: NaN(SiMe₃)2 / tetrahydrofuran; toluene / 0.25 h / 25 °C

5: 83 percent / toluene / -78 - -20 deg C, 45 min; 0 deg C, 30 min; 0 deg C - RT, 15 min

6: 97 percent / DIBAL / toluene; tetrahydrofuran / -78 deg C, 30 min; -78 - -50 deg C, 30 min

With dmap; Schwartz's reagent; iodine; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ja00216a026