(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

Base Information

Chemical Name:(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate
CAS No.:119972-88-2
Molecular Formula:C₁₅H₂₀O₄
Molecular Weight:264.321
Hs Code.:

Synonyms:(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

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Chemical Property of (1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

Chemical Property:

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Technology Process of (1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

There total 6 articles about (1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 120053-15-8
(1S,2R)-2-(methoxymethoxy)cyclohexanol

: 65-85-0,8013-63-6
benzoic acid

: 119972-88-2
(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jo00272a027

Reference yield:

: 1792-81-0
cis-1,2-cyclohexane

: 119972-88-2
(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / tetrahydrofuran / 0.5 h / 0 °C

2: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH₂Cl₂ / 22 h / -40 °C

3: 97 percent Spectr_. / TiCl₄ / CH₂Cl₂ / 1 h / -85 °C

4: ethyldiisopropylamine / CH₂Cl₂ / Ambient temperature

5: 0.5 N t-BuOK / 2-methyl-propan-2-ol / 2 h / 60 °C

6: 40 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 3 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00272a027

Reference yield:

: 39789-20-3
cis-1,2-bis(trimethylsilyloxy)cyclohexane

: 119972-88-2
(1S,2S)-2-(methoxymethoxy)cyclohexyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: trimethylsilyl trifluoromethanesulfonate (TMSOTf) / CH₂Cl₂ / 22 h / -40 °C

2: 97 percent Spectr_. / TiCl₄ / CH₂Cl₂ / 1 h / -85 °C

3: ethyldiisopropylamine / CH₂Cl₂ / Ambient temperature

4: 0.5 N t-BuOK / 2-methyl-propan-2-ol / 2 h / 60 °C

5: 40 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 3 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00272a027