Technology Process of N6-(2,4-difluorophenyl)-1H-pyrazolo[3,4-b]pyridine-3,6-diamine
There total 6 articles about N6-(2,4-difluorophenyl)-1H-pyrazolo[3,4-b]pyridine-3,6-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-(2,4-difluorophenylamino)-2-(methylthio)nicotinonitrile;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
With
hydrazine hydro-chloride;
In
propan-1-ol; water;
at 90 ℃;
for 6h;
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
at 110 ℃;
With
hydrazine hydrate;
In
ethanol;
at 90 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: water; lithium hydroxide monohydrate / ethanol / 2 h / 60 °C
1.2: pH 1
2.1: diphenylether / 4 h / 250 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.75 h / 20 °C / Inert atmosphere
4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
5.2: 6 h / 90 °C
With
lithium hydroxide monohydrate; potassium tert-butylate; water; caesium carbonate; 3-chloro-benzenecarboperoxoic acid;
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; diphenylether; ethanol; dichloromethane;
