digoxin 3''-hemisuccinate p-nitrophenyl ester

Base Information

Chemical Name:digoxin 3''-hemisuccinate p-nitrophenyl ester
CAS No.:297183-94-9
Molecular Formula:C₅₁H₇₁NO₁₉
Molecular Weight:1002.12
Hs Code.:

Synonyms:digoxin 3''-hemisuccinate p-nitrophenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of digoxin 3''-hemisuccinate p-nitrophenyl ester

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Technology Process of digoxin 3''-hemisuccinate p-nitrophenyl ester

There total 2 articles about digoxin 3''-hemisuccinate p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: digoxin 3''-hemisuccinate

: 297183-94-9
digoxin 3''-hemisuccinate p-nitrophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In 1,4-dioxane; at 20 ℃; for 4h;
DOI:10.1248/bpb.23.906

Reference yield:

: 20830-75-5
digoxin

: 297183-94-9
digoxin 3''-hemisuccinate p-nitrophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic anhydride; formic acid / pyridine / 4 h / cooling

1.2: pyridine / 73 h / 70 °C

1.3: 16 percent / NaHCO₃ / methanol / 3 h / 60 - 70 °C

2.1: 91 percent / dicyclohexylcarbodiimide / dioxane / 4 h / 20 °C

With formic acid; acetic anhydride; dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine;
DOI:10.1248/bpb.23.906