methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

Base Information

Chemical Name:methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate
CAS No.:1159001-78-1
Molecular Formula:C₁₇H₁₅NO₂
Molecular Weight:265.312
Hs Code.:

Synonyms:methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

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Chemical Property of methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

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Technology Process of methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

There total 4 articles about methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 79230-01-6
(Z)-methyl 3-phenyl-3-(p-tolylamino)acrylate

: 1159001-78-1
methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

Guidance literature:: With [bis(acetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 60 ℃; for 4h;
DOI:10.1021/ol900576a

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 86971-60-0
(Z)-3-amino-3-phenylacrylic acid methyl ester

: 1159001-78-1
methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate; potassium hydrogencarbonate; copper diacetate; n-tetradecanoic acid; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl-formamide / 24 h / 100 °C / Schlenk technique; Sealed tube

2: N,N-dimethyl-formamide; dimethyl sulfoxide / 24 h / 130 °C

With potassium permanganate; copper diacetate; potassium hydrogencarbonate; n-tetradecanoic acid; tri tert-butylphosphoniumtetrafluoroborate; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Chan-Lam Coupling;
DOI:10.1039/d0ra04592f

Reference yield:

: 614-27-7
methyl 3-oxo-3-phenylpropionate

: 1159001-78-1
methyl 5-methyl-2-phenyl-1H-indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 80 °C / Inert atmosphere

2: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere

With copper diacetate; palladium diacetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo4023292