(S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate
• CAS No.: 1422056-69-6
• Molecular Formula: C₂₀H₂₉NO₄
• Molecular Weight: 347.455
• Mol file: 1422056-69-6.mol

Synonyms:(S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Chemical Property of (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

There total 1 articles about (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-Hexen-1-ol (821-41-0) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate (1422056-69-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/ja401022x

Reference yield: 67.0%

Togni's reagent II (887144-94-7) + (S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate (1422056-69-6) → (S)-7,7,7-trifluoroheptyl 2-(tert-butoxycarbonylamino)-3-phenylpropanoate (1422056-46-9)

Guidance literature:

With 4-methyl-morpholine; at 25 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01301

Reference yield: 44.0%

(S)-hex-5-en-1-yl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate (1422056-69-6) + Umemoto's reagent (129946-88-9) → (S)-7,7,7-trifluoroheptyl 2-(tert-butoxycarbonylamino)-3-phenylpropanoate (1422056-46-9)

Guidance literature:

With pyridine; methanol; Ru(2,2'-bipyridine)₃Cl₂·6H₂O; at 25 ℃; for 24h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/ja401022x

upstream raw materials:

5-Hexen-1-ol

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

(S)-7,7,7-trifluoroheptyl 2-(tert-butoxycarbonylamino)-3-phenylpropanoate