Technology Process of 3-benzyloxy-2,4,6-tribromo-5-(1,3-dioxolan-2-yl)pyridine
There total 5 articles about 3-benzyloxy-2,4,6-tribromo-5-(1,3-dioxolan-2-yl)pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,4,6-tribromo-5-(1,3-dioxolan-2-yl)pyridin-3-ol;
With
potassium carbonate; potassium iodide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.3987/COM-11-12239
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 65 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / toluene / 0.25 h / 90 °C / Inert atmosphere
2.2: 5 h / 110 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol / 27 h / 20 °C
4.1: triethylamine / methanol; dichloromethane / -50 °C / Inert atmosphere
4.2: 3 h / -50 - -35 °C / Inert atmosphere
5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere
5.2: 6 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium iodide;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-11-12239
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 27 h / 20 °C
2.1: triethylamine / methanol; dichloromethane / -50 °C / Inert atmosphere
2.2: 3 h / -50 - -35 °C / Inert atmosphere
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 6 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; potassium iodide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-11-12239
