(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

Base Information

Chemical Name:(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid
CAS No.:1236289-30-7
Molecular Formula:C₂₁H₂₀N₂O₅
Molecular Weight:380.4
Hs Code.:

Synonyms:(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

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Chemical Property of (E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

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Technology Process of (E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

There total 3 articles about (E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1236289-20-5
(E)-ethyl 3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylate

: 1236289-30-7
(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

Guidance literature:: With sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.04.076

Reference yield:

: 1-(4'-methoxyphenyl)-2-(1''-(3,'''5'''-dimethoxyphenyl)ethylidene)hydrazine

: 1236289-30-7
(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3,5-trichloro-2,4,6-triazine / 2 h / 20 °C / Inert atmosphere

2: acetonitrile / Reflux; Inert atmosphere

3: sodium hydroxide / ethanol; dimethyl sulfoxide / Inert atmosphere

With 1,3,5-trichloro-2,4,6-triazine; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile; 2: |Wittig Olefination;
DOI:10.2174/157340612802084252

Reference yield:

: 1201-38-3
2',5'-dimethoxyacetophenone

: 1236289-30-7
(E)-3-(1'-(4''-methoxyphenyl)-3'-(2''',5'''-dimethoxyphenyl)-1'H-pyrazol-4'-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; triethylamine / ethanol / 20 °C / Inert atmosphere

2: 1,3,5-trichloro-2,4,6-triazine / 2 h / 20 °C / Inert atmosphere

3: acetonitrile / Reflux; Inert atmosphere

4: sodium hydroxide / ethanol; dimethyl sulfoxide / Inert atmosphere

With 1,3,5-trichloro-2,4,6-triazine; acetic acid; triethylamine; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile; 3: |Wittig Olefination;
DOI:10.2174/157340612802084252