Technology Process of Methyl (2S,3R,4R,5S)-2-benzyl-5-<(tert-butoxycarbonyl)amino>-3,4-epoxy-6-phenylhexanoate
There total 7 articles about Methyl (2S,3R,4R,5S)-2-benzyl-5-<(tert-butoxycarbonyl)amino>-3,4-epoxy-6-phenylhexanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / CH2Cl2 / Ambient temperature
2: DMSO, oxalyl chloride, diisopropylethylamine / CH2Cl2 / -78 deg C, 30 min then warm to room temp.
4: 71 percent / Jones' reagent / acetone / 0.5 h / 0 °C
5: 89 percent / diethyl ether / Ambient temperature
6: 73 percent / m-chloroperbenzoic acid / CH2Cl2 / 40 h / Ambient temperature
With
jones' reagent; oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; acetone;
DOI:10.1021/jo00084a037
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / LiAlH4 / diethyl ether / Ambient temperature
2: triethylamine / CH2Cl2 / Ambient temperature
3: DMSO, oxalyl chloride, diisopropylethylamine / CH2Cl2 / -78 deg C, 30 min then warm to room temp.
5: 71 percent / Jones' reagent / acetone / 0.5 h / 0 °C
6: 89 percent / diethyl ether / Ambient temperature
7: 73 percent / m-chloroperbenzoic acid / CH2Cl2 / 40 h / Ambient temperature
With
lithium aluminium tetrahydride; jones' reagent; oxalyl dichloride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; acetone;
DOI:10.1021/jo00084a037
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 77 percent / K2CO3 / acetone / Heating
2: 100 percent / LiAlH4 / diethyl ether / Ambient temperature
3: triethylamine / CH2Cl2 / Ambient temperature
4: DMSO, oxalyl chloride, diisopropylethylamine / CH2Cl2 / -78 deg C, 30 min then warm to room temp.
6: 71 percent / Jones' reagent / acetone / 0.5 h / 0 °C
7: 89 percent / diethyl ether / Ambient temperature
8: 73 percent / m-chloroperbenzoic acid / CH2Cl2 / 40 h / Ambient temperature
With
lithium aluminium tetrahydride; jones' reagent; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; acetone;
DOI:10.1021/jo00084a037
