11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

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Chemical Name:11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
CAS No.:183554-54-3
Molecular Formula:C₂₅H₂₃ClN₂
Molecular Weight:386.924
Hs Code.:

Synonyms:11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

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Chemical Property of 11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

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Technology Process of 11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

There total 4 articles about 11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 183554-52-1
1-Benzyl-3-[8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-pyrrolidin-2-one

: 183554-54-3
11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -5 ℃; for 2h;
DOI:10.1016/S0968-0896(98)00026-1

Reference yield:

: 5291-77-0
1-benzyl-2-pyrrolidone

: 183554-54-3
11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi, i-Pr₂NH / hexane; tetrahydrofuran / 1.) -78 deg C, 30 min; -78 deg C to -5 deg C, 60 min, 2.) -78 deg C, 1 h; -78 deg C to -10 deg C, 1 h

2: conc.H₂SO₄ / 4 h / 80 °C

3: 54 percent / LAH / tetrahydrofuran / 2 h / -5 °C

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1016/S0968-0896(98)00026-1

Reference yield:

: 31251-41-9
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

: 183554-54-3
11-[1-Benzyl-pyrrolidin-(3Z)-ylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi, i-Pr₂NH / hexane; tetrahydrofuran / 1.) -78 deg C, 30 min; -78 deg C to -5 deg C, 60 min, 2.) -78 deg C, 1 h; -78 deg C to -10 deg C, 1 h

2: conc.H₂SO₄ / 4 h / 80 °C

3: 54 percent / LAH / tetrahydrofuran / 2 h / -5 °C

With lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1016/S0968-0896(98)00026-1