31251-41-9Relevant articles and documents
Method for preparing anti-allergic rhinitis medicine loratadine intermediate
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Paragraph 0056-0092, (2018/07/30)
The invention belongs to the technical field of chemical medicine preparation and particularly relates to a method for preparing an anti-allergic rhinitis medicine, namely a loratadine intermediate. According to the method, ammonium meta-tungstate is adopted as a WO3 precursor, ZrOC12*8H2O is adopted as a ZrO2 precursor, and a WO3/ZrO2 solid super-strong acid is supported by sulfamic acid graftingmodified silica gel, and then a silica gel supported solid acid is prepared. As 8-chlorine-5,6-dihydro-11H-benzo[5,6] cycloheptane[1,2-b] pyridine-11-ketone is prepared from the novel silica gel supported solid acid through catalysis, the problem of excessive wastewater is overcome, the environment protection burden is alleviated, and the reaction yield can be increased.
Aza-analogue dibenzepinone scaffolds as p38 mitogen-activated protein kinase inhibitors:Design, synthesis, and biological data of inhibitors with improved physicochemical properties
Karcher, Solveigh C.,Laufer, Stefan A.
supporting information; experimental part, p. 1778 - 1782 (2010/03/01)
We recently described a promising novel class of p38 mitogen activated protein (MAP) kinase inhibitors with dibenzepinone-scaffolds. To optimize their physicochemical properties, characterized by calculated log P values and measured lipophilicity (chromatographic hydrophobicity index=CHI), we synthesized aza-analogue dibenzepinones. Here, we present the synthesis and biological data of compounds with the novel aza-dibenzepinone scaffolds. Although these aza-analogues revealed an improved aqueous solubility, introduction of nitrogen was not effective in the p38 MAPK enzyme assay.
A PROCESS FOR PREPARING BENZOCYCLOHETAPYRIDIN-11-ONES
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Page 6, (2008/06/13)
A process for the preparation of benzocydoheptapyridin-11-ones of the general formula (III) wherein R1, R2, R3, R4, R5, R6 and R7 are independently selected from one or more of the following groups: hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, which comprises a) reacting a compound of general formula (I), wherein R1, R2, R3, R4, R5, R6 and R7are as defined above, with anhydrous HF/BF3 at a temperature in the range of -100°C to -20°C, to produce a compound of formula (II), wherein R1, R2 R3, R4, R5, R6and R7 are as defined above; and hydrolysing it to compound of formula (III).