N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Base Information

Chemical Name:N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide
CAS No.:1616929-80-6
Molecular Formula:C₂₁H₁₇FN₄OS
Molecular Weight:392.457
Hs Code.:

Synonyms:N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

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Technology Process of N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

There total 6 articles about N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1616930-29-0
C₁₅H₁₃N₃O₂S

: 371-40-4
4-fluoroaniline

: 1616929-80-6
N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 156001-51-3
3-Bromo-6-methyl-benzonitrile

: 1616929-80-6
N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / diethyl ether / 2 h / 20 °C

1.2: 4 h / Reflux

2.1: ethanol; sodium / diethyl ether / 20 h / 20 °C

3.1: ethanol / 1 h / 0 - 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 5 h / 90 °C

5.1: sodium hydroxide / ethanol / 2 h / 80 °C

6.1: HATU; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; ethanol; sodium; magnesium; triethylamine; HATU; sodium hydroxide; In diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile; 4.1: |Stille Cross Coupling;

Reference yield:

: 1616930-26-7
C₁₃H₁₃BrO₄

: 1616929-80-6
N-(4-fluorophenyl)-1-methyl-5-(2-methyl-5-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 1 h / 0 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 5 h / 90 °C

3: sodium hydroxide / ethanol / 2 h / 80 °C

4: HATU; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; HATU; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile; 2: |Stille Cross Coupling;