4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

Base Information

Chemical Name:4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide
CAS No.:1382451-63-9
Molecular Formula:C₂₆H₂₈N₆O
Molecular Weight:440.548
Hs Code.:

Synonyms:4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

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Chemical Property of 4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

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Technology Process of 4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

There total 6 articles about 4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1382451-98-0
3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

: 1382451-63-9
4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

Guidance literature:: With water; In acetonitrile; for 1h; Reflux;

Reference yield:

: 87597-21-5
ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

: 1382451-63-9
4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

4.1: N,N-dimethyl-formamide / 3 h / 23 °C

5.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

6.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

6.2: 1 h

7.1: manganese(IV) oxide; sodium cyanide

8.1: hydrazine hydrate / methanol / 13 h / Reflux

9.1: hydrogenchloride; sodium nitrite / water / 1 h / 23 °C

10.1: water / acetonitrile / 1 h / Reflux

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; water; diisobutylaluminium hydride; potassium carbonate; hydrazine hydrate; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1382451-75-3
(6,8-dibromo-3-iodoimidazo[1,2-a]pyrazin-2-yl)methanol

: 1382451-63-9
4-[2-amino-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

2.1: N,N-dimethyl-formamide / 3 h / 23 °C

3.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

4.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

4.2: 1 h

5.1: manganese(IV) oxide; sodium cyanide

6.1: hydrazine hydrate / methanol / 13 h / Reflux

7.1: hydrogenchloride; sodium nitrite / water / 1 h / 23 °C

8.1: water / acetonitrile / 1 h / Reflux

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; potassium phosphate; oxalyl dichloride; water; potassium carbonate; hydrazine hydrate; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;