3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

Base Information

Chemical Name:3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide
CAS No.:1382451-98-0
Molecular Formula:C₂₇H₂₆N₈O₂
Molecular Weight:494.556
Hs Code.:

Synonyms:3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

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Chemical Property of 3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

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Technology Process of 3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

There total 7 articles about 3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1382451-93-5
N-cyclopropyl-4-[2-(hydrazinocarbonyl)-8-(isobutylamino)6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide

: 1382451-98-0
3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; at 23 ℃; for 1h;

Reference yield:

: 87597-21-5
ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

: 1382451-98-0
3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

4.1: N,N-dimethyl-formamide / 3 h / 23 °C

5.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

6.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

6.2: 1 h

7.1: manganese(IV) oxide; sodium cyanide

8.1: hydrazine hydrate / methanol / 13 h / Reflux

9.1: hydrogenchloride; sodium nitrite / water / 1 h / 23 °C

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; hydrazine hydrate; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1382451-75-3
(6,8-dibromo-3-iodoimidazo[1,2-a]pyrazin-2-yl)methanol

: 1382451-98-0
3-[4-(cyclopropylcarbamoyl)phenyl]-8-(isobutylamino)-6-phenylimidazo[1,2-a]pyrazine-2-carbonyl azide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.5 h / 100 °C / microwave radiation

2.1: N,N-dimethyl-formamide / 3 h / 23 °C

3.1: potassium carbonate; triphenylphosphine / water; propan-1-ol / 2 h / 120 °C / microwave irradiation

4.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.33 h / -78 °C / Inert atmosphere

4.2: 1 h

5.1: manganese(IV) oxide; sodium cyanide

6.1: hydrazine hydrate / methanol / 13 h / Reflux

7.1: hydrogenchloride; sodium nitrite / water / 1 h / 23 °C

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; potassium phosphate; oxalyl dichloride; potassium carbonate; hydrazine hydrate; triphenylphosphine; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;