(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

Base Information

Chemical Name:(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide
CAS No.:924644-83-7
Molecular Formula:C₃₁H₅₁N₅O₇
Molecular Weight:605.775
Hs Code.:

Synonyms:(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

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Chemical Property of (S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

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Technology Process of (S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

There total 3 articles about (S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 924645-00-1
9-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-1,5,9triaza-cyclododecane-1,5-dicarboxylic acid di-tert-butyl ester

: 593-51-1
methylamine hydrochloride

: 924644-83-7
(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 144h; pH=10;
DOI:10.1021/jo061754k

Reference yield:

: 26054-60-4
((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester

: 924644-83-7
(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / acetonitrile / 168 h / 40 °C

2: 90 percent / EDC*HCl; 1-hydroxy-7-azabenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 144 h / 20 °C / pH 10

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo061754k

Reference yield:

: 174192-40-6
bis(1,1-dimethylethyl) 1,5,9-triazacyclododecane-1,5-dicarboxylate

: 924644-83-7
(S)-(benzyloxycarbonylamino)-3-[5,9-di(tert-butyloxycarbonyl)-1,5,9-triazacyclododec-1-yl]-N-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / acetonitrile / 168 h / 40 °C

2: 90 percent / EDC*HCl; 1-hydroxy-7-azabenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 144 h / 20 °C / pH 10

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo061754k