2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde

Base Information

• Chemical Name: 2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde
• CAS No.: 867267-27-4
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.191
• DSSTox Substance ID: DTXSID901214481
• Nikkaji Number: J2.589.815J

Synonyms:2-methoxy-5-(methoxymethoxy)isonicotinaldehyde;867267-27-4;2-methoxy-5-methoxymethoxy-pyridine-4-carbaldehyde;2-Methoxy-5-(methoxymethoxy)pyridine-4-carbaldehyde;SCHEMBL15064965;CLADBSZPHROUKB-UHFFFAOYSA-N;DTXSID901214481;BS-46721;CS-0161386;E75480;2-methoxy-5-methoxymethoxypyridine-4-carbaldehyde;A934738;2-Methoxy-5-(methoxymethoxy)-4-pyridinecarboxaldehyde

Chemical Property of 2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 197.06880783
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCOC1=CN=C(C=C1C=O)OC

Technology Process of 2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde

There total 1 articles about 2-Methoxy-5-(methoxymethoxy)isonicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxypyridine-3-ol (51834-97-0) → 2-methoxy-5-methoxymethoxy-pyridine-4-carbaldehyde (867267-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / NaH / dimethylformamide / 3 h / 20 °C

2.1: MeLi; diisopropylamine / tetrahydrofuran / 3 h / 0 °C

2.2: 62 percent / tetrahydrofuran / 2 h / -40 °C

With methyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-871946

Reference yield:

2-methoxy-5-methoxymethoxy-pyridine-4-carbaldehyde (867267-27-4) → 2-methoxy-5-[[2-(2-methoxyphenyl)pyridin-3-yl]methoxy]pyridine-4-carbaldehyde bis(trifluoroacetic acid)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran

2: potassium carbonate / acetonitrile

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

2-methoxy-5-methoxymethoxy-pyridine-4-carbaldehyde (867267-27-4) → 2-methoxy-5-[[2-(3-methoxyphenyl)pyridin-3-yl]methoxy]pyridine-4-carbaldehyde bis(trifluoroacetic acid)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran

2: trifluoroacetic acid; potassium carbonate / acetonitrile

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;

upstream raw materials:

6-methoxypyridine-3-ol

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