5-Hydroxy-2-methoxypyridine

Base Information

• Chemical Name: 5-Hydroxy-2-methoxypyridine
• CAS No.: 51834-97-0
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 2933399090
• European Community (EC) Number: 690-478-2
• DSSTox Substance ID: DTXSID30469560
• Nikkaji Number: J3.358.761I
• Wikidata: Q72484954
• Mol file: 51834-97-0.mol

Synonyms:5-Hydroxy-2-methoxypyridine;51834-97-0;6-methoxypyridin-3-ol;5-Hydroxy-2-methoxylpyridine;2-Methoxy-5-hydroxypyridine;MFCD06858737;3-Pyridinol, 6-methoxy-;6-Methoxy-3-pyridinol;6-METHOXY-PYRIDIN-3-OL;6-Methoxy-3-hydroxypyridine;SCHEMBL177831;DTXSID30469560;LKBKDKVMHWPZDB-UHFFFAOYSA-N;6-Methoxy-3-pyridinol, AldrichCPR;AKOS006346491;CS-W005101;PS-4956;AC-23447;SY022315;A7631;AM20061275;BB 0261039;FT-0600712;EN300-118796;J-518862;Z1201623942

Chemical Property of 5-Hydroxy-2-methoxypyridine

Chemical Property:

• Vapor Pressure: 8.83E-05mmHg at 25°C
• Melting Point: 81 °C
• Refractive Index: 1.538
• Boiling Point: 330.1 °C at 760 mmHg
• PKA: 9.69±0.10(Predicted)
• Flash Point: 153.5 °C
• PSA: 42.35000
• Density: 1.19 g/cm³
• LogP: 0.79580
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

5-Hydroxy-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC=C(C=C1)O
• Uses: 5-Hydroxy-2-methoxypyridine, is a heterocyclic building block used in various chemical synthesis.

Technology Process of 5-Hydroxy-2-methoxypyridine

There total 16 articles about 5-Hydroxy-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(benzyloxy)-2-methoxypyridine (1083329-15-0) → 6-methoxypyridine-3-ol (51834-97-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.3762/bjoc.9.313

Reference yield: 93.0%

2-methoxy-pyridine-5-boronic acid (163105-89-3,600726-67-8) → 6-methoxypyridine-3-ol (51834-97-0)

Guidance literature:

With [Zn₃(biphenyl-4,4′-dicarboxylato)₃(4,4'-bipyridine)]*2DMF*4H₂O; dihydrogen peroxide; In water; at 20 ℃; for 0.333333h; Reagent/catalyst;

DOI:10.1039/d0dt00794c

Reference yield: 91.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) → 6-methoxypyridine-3-ol (51834-97-0)

Guidance literature:

2-methoxy-5-bromopyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With Trimethyl borate; at -78 - 20 ℃; for 9h;

With dihydrogen peroxide; In water; for 3h;

DOI:10.1007/s00044-012-0180-1

upstream raw materials:

5-acetoxy-2-methoxy-pyridine

2-methoxy-5-bromopyridine

6-methoxy-pyridin-3-ylamine

Trimethyl borate

Downstream raw materials:

pyridine-2,5-diol

2-methoxy-5-(methoxymethoxy)pyridine

2-methoxy-5-(triisopropylsilanyloxy)pyridine

2,5-dimethoxypyridine