3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

Base Information

Chemical Name:3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline
CAS No.:169129-77-5
Molecular Formula:C₂₀H₂₁F₃N₂O₅S
Molecular Weight:458.458
Hs Code.:

Synonyms:3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

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Chemical Property of 3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

Chemical Property:

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Technology Process of 3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

There total 4 articles about 3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 169129-76-4
3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>indoline

: 169129-77-5
3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

Guidance literature:: With triethylamine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ja00141a004

Reference yield:

: 39828-35-8
2,4-dimethoxybenzoyl chloride

: 169129-77-5
3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.33 h / Ambient temperature

2: 71 percent / BH₃*THF, TFA / tetrahydrofuran / 0.5 h / 0 °C

3: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

With borane-THF; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00141a004

Reference yield:

: 91-52-1
2,4 dimethoxybenzoic acid

: 169129-77-5
3-<2-<(2,4-dimethoxybenzoyl)amino>ethyl>-N-<(trifluoromethyl)sulfonyl>indoline

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 0.5 h / 0 - 20 °C

2: Et₃N / tetrahydrofuran / 0.33 h / Ambient temperature

3: 71 percent / BH₃*THF, TFA / tetrahydrofuran / 0.5 h / 0 °C

4: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

With borane-THF; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00141a004