{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

Base Information

Chemical Name:{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile
CAS No.:712273-61-5
Molecular Formula:C₁₆H₁₁N₃O₂
Molecular Weight:277.282
Hs Code.:

Synonyms:{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

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Chemical Property of {3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

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Technology Process of {3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

There total 3 articles about {3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 109-77-3
malononitrile

: 478929-29-2
3-hydroxy-3-(4-hydroxyphenyl)butan-2-one

: 712273-61-5
{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

Guidance literature:: With ammonium acetate; acetic acid; In pyridine; at 20 ℃; for 16h;
DOI:10.1039/b315274j

Reference yield:

: 149683-53-4
4-(tert-butyldimethylsilyloxy)acetophenone

: 712273-61-5
{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - -10 °C

2.1: 2.3 g / TBAF / tetrahydrofuran / 2 h / 20 °C

3.1: 51 percent / AcOH; NH₄OAc / pyridine / 16 h / 20 °C

With ammonium acetate; tetrabutyl ammonium fluoride; tert.-butyl lithium; acetic acid; In tetrahydrofuran; pyridine;
DOI:10.1039/b315274j

Reference yield:

: 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-butan-2-one

: 712273-61-5
{3-cyano-4,5-dimethyl-5-(4-hydroxyphenyl)-2(5H)-furanylidene}propanedinitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 2.3 g / TBAF / tetrahydrofuran / 2 h / 20 °C

2: 51 percent / AcOH; NH₄OAc / pyridine / 16 h / 20 °C

With ammonium acetate; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; pyridine;
DOI:10.1039/b315274j