Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

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Chemical Name:Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester
CAS No.:183145-32-6
Molecular Formula:C₆₀H₉₂Br₂N₂O₁₈P₂
Molecular Weight:1351.15
Hs Code.:

Synonyms:Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

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Chemical Property of Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

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Technology Process of Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

There total 3 articles about Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183145-05-3
Undec-10-ynoic acid (S)-3-benzyloxy-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl ester

: 183145-32-6
Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / O₂, CuCl, TMEDA / xylene / 0.75 h / 140 - 150 °C

2: 98 percent / H₂ / Pd/C / ethanol; acetic acid; ethyl acetate / 20 °C

3: 1.) 1H-tetrazole, 2.) aq. H₂O₂ / 1) THF, rt, 30 min; 2) THF, 15 min

With 1H-tetrazole; N,N,N,N,-tetramethylethylenediamine; hydrogen; dihydrogen peroxide; oxygen; copper(l) chloride; palladium on activated charcoal; In ethanol; acetic acid; ethyl acetate; xylene;
DOI:10.1021/jo9605455

Reference yield:

: 183145-15-5
Docosa-10,12-diynedioic acid bis-{(S)-3-benzyloxy-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

: 183145-32-6
Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / Pd/C / ethanol; acetic acid; ethyl acetate / 20 °C

2: 1.) 1H-tetrazole, 2.) aq. H₂O₂ / 1) THF, rt, 30 min; 2) THF, 15 min

With 1H-tetrazole; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In ethanol; acetic acid; ethyl acetate;
DOI:10.1021/jo9605455

Reference yield:

: 132270-46-3
2-cyanoethyl-2-bromoethyl-(N,N-di-i-propylamino)phosphoramidite

: 183145-25-7
Docosanedioic acid bis-{(S)-3-hydroxy-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

: 183145-32-6
Docosanedioic acid bis-{(R)-3-[(2-bromo-ethoxy)-(2-cyano-ethoxy)-phosphoryloxy]-2-[4-(4-methoxy-phenyl)-butyryloxy]-propyl} ester

Guidance literature:: With 1H-tetrazole; dihydrogen peroxide; Yield given. Multistep reaction; 1) THF, rt, 30 min; 2) THF, 15 min;
DOI:10.1021/jo9605455