MRS 1353

Base Information

• Chemical Name: MRS 1353
• CAS No.: 192053-06-8
• Molecular Formula: C₃₄H₂₈Cl₃NO₆
• Molecular Weight: 652.958
• Mol file: 192053-06-8.mol

Synonyms:MRS 1353

Chemical Property of MRS 1353

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MRS 1353

There total 9 articles about MRS 1353 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Ethoxymethyl-2-methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[4-(2,2,2-trichloro-ethoxycarbonyl)-benzyl] ester (1026624-78-1) → MRS 1353 (192053-06-8)

Guidance literature:

With hydrogenchloride; In acetone; at 45 ℃; Yield given;

DOI:10.1021/jm970091j

Reference yield:

Phenylpropargyl aldehyde (2579-22-8) → MRS 1353 (192053-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 16 percent / ethanol / Heating

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: 85 percent / TBAF / dimethylformamide / 2 h / Ambient temperature

4: K₂CO₃ / acetone / Heating

5: aq. HCl / acetone / 45 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm970091j

Reference yield:

ethyl (E)-3-aminobut-2-enoate (41867-20-3) → MRS 1353 (192053-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 16 percent / ethanol / Heating

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: 85 percent / TBAF / dimethylformamide / 2 h / Ambient temperature

4: K₂CO₃ / acetone / Heating

5: aq. HCl / acetone / 45 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm970091j

upstream raw materials:

1-Ethoxymethyl-2-methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[4-(2,2,2-trichloro-ethoxycarbonyl)-benzyl] ester

Phenylpropargyl aldehyde

ethyl (E)-3-aminobut-2-enoate

4-methyl-benzoyl chloride