41867-20-3

Basic information

• Product Name: 2-Butenoic acid, 3-amino-, ethyl ester, (2E)-
• Synonyms: 3-aminobut-2-enoic acid ethyl ester;ETHYL-(2E)-3-AMINOBUT-2-ENOATE;β-amino-ethylcrotonate;ethyl (Z)-β-aminocrotonate;ethyl β-aminocrotonate;2-Butenoic acid, 3-amino-, ethyl ester, (E)-;β-aminocrotonic acid ethyl ester
• CAS NO: 41867-20-3
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Mol File: 41867-20-3.mol
• Article Data: 49

Chemical Properties

• Melting Point: 34°C
• Boiling Point: 239.22°C (rough estimate)
• Density: 1.0219
• Refractive Index: 1.4988 (estimate)
• CAS DataBase Reference: 2-Butenoic acid, 3-amino-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-amino-, ethyl ester, (2E)-(41867-20-3)
• EPA Substance Registry System: 2-Butenoic acid, 3-amino-, ethyl ester, (2E)-(41867-20-3)

Safety Data

• Hazardous Substances Data: 41867-20-3(Hazardous Substances Data)

Upstream product

• 4341-76-8 Ethyl 2-butynoate 
• 141-97-9 ethyl acetoacetate 
• 6127-92-0 E-Ethyl β-chlorocrotonate 
• 7664-41-7 ammonia 
• 412321-15-4 4-cyano-3-methyl-pentenedioic acid diethyl ester 
• 91558-49-5 2,3-dicyano-3-methyl-glutaric acid diethyl ester 
• 73758-52-8 3-amino-3-ureido-butyric acid ethyl ester 
• 56294-09-8 ethyl 5-methoxycarbonyl-3-oxopentanoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-36-2 ethyl bromoacetate 
• 75-05-8 acetonitrile 
• 14063-82-2 4-chloro-2H-chromene-3-carboxaldehyde 
• 141-78-6 ethyl acetate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 52199-37-8 2,4-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 23652-67-7 ethyl (Z)-β-acetylaminobut-2-enoate 
• 23652-67-7 methyl (E)-3-acetamido-2-butenoate 
• 78120-37-3 (E)-ethyl 2-acetyl-3-aminobut-2-enoate 
• 53274-27-4 diethyl 1,4-dihydro-2,6-dimethyl-4-(4-quinolinyl)pyridine-3,5-dicarboxylate 
• 2199-54-4 2,4,5-trimethyl-3-ethoxycarbonylpyrrole 
• 115951-98-9 1,4-bis(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-yl)benzene 
• 15866-05-4 6-methyl-2-thioxo-3-p-tolyl-2,3-dihydro-1H-pyrimidin-4-one 
• 70463-75-1 2-(1-amino-ethylidene)-N-(4-chloro-phenyl)-malonamic acid ethyl ester 
• 71814-38-5 3-[N'-(4-chloro-phenyl)-ureido]-crotonic acid ethyl ester 
• 21829-28-7 2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 21881-54-9 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 63093-76-5 ethyl 5-cyano-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3-carboxylate 
• 1165-06-6 Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Condensation of 4-chloro-2H-chromene-3-carbaldehydes and ethyl-3-aminocrotonates with p-TsOH: a facile approach for the synthesis of chromenyldihydropyridines

The investigated reaction of 4-chloro-2H-chromene-3-carbaldehyde 1a with ethyl 3-oxobutanoate 2a in the presence of ammonium acetate provided two compounds, 2H-chromenyldihydropyridine dicarboxylate 3a and chromenopyridine carboxylate 4a. However, the reaction of 1a with ethyl-3-aminocrotonate 5a in the presence of p-TsOH provided selectively 2H-chromenyldihydropyridine dicarboxylate 3a with very good yield. The established method was applied for the preparation of series of 2H-chromenyldihydropyridine dicarboxylates 3a–q.

-

-

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

Synthesis and Biological Activities of Nicotinaldehyde Based 1,4-Dihydropyridinedicarboxylates

Abstract: 1,4-Dihydropyridinecarboxylates were prepared by the reaction of nicotinaldehydes with aminocrotonoates in the presence of p-TsOH at room temperature. The prepared compounds were evaluated for their anti-microbial, free-radical scavenging and α-glucosidase inhibitory activities. Compounds diethyl 2,6-diphenyl-4-(pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 4-(2-chloro-5-(4-fluorophenyl)pyridin-3-yl)-2,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylate were identified as potent anti-fungal agents. The compounds diethyl 2,6-dimethyl-4-(pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate, dimethyl 4-(2-chloropyridin-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 2,6-dimethyl-4-(pyridin-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate were identified as ABT?+ free radical scavengers. The compounds diethyl 4-(2-chloro-5-phenylpyridin-3-yl)-2,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylate and diethyl 4-(2-chloro-5-phenylpyridin-3-yl)-2,6-diphenyl-1,4-dihydropyridine-3,5-dicarboxylate denoted α-glucosidase inhibitory activity.